Background: Presynaptic forms of congenital myasthenic syndromes (CMS) due to pathogenic variants in SLC18A3 impairing the synthesis and recycling of acetylcholine (ACh) have recently been described.SLC18A3 encodes the vesicular ACh transporter (VAChT), modulating the active transport of ACh at the neuromuscular junction, and homozygous loss of VAC
Specialized proteins serve as scaffolds sculpting strongly curved membranes of intracellular organelles.Effective membrane shaping requires segregation of these proteins into domains and is, therefore, critically dependent on the protein-protein interaction.Interactions mediated by membrane elastic deformations have been extensively analyzed within
In the rotary steering system of oil drilling, both power and data transmission are needed.This paper presents a parallel power and data transmission method for a rotating steering system Zeaxanthin with output voltage control.To reduce the size of the system, power and data are transmitted through the same rotational coupling mechanism.A power tra
Early Childhood students may participate in a 3 months internship in 3 African countries.We have challenged a group of students from the last 5 years of the program to respond Tasting Glasses to how they experienced the religious atmosphere in and outside the kindergartens.Although their own home country has a strong Christian heritage, the present
Vase (Set of 3) Iatrogenic valvular regurgitation following cardiac surgery has been reported as a result of leaflet perforation or entrapment.Due to its central location, the aortic valve is one of the most vulnerable structures for iatrogenic injuries.Proper assessment of the aortic valve by transesophageal echocardiography (TEE) Digital Probe Th